Doxycycline works in rosacea by reducing inflammation.
Isotretinoin works by reducing the size of oil-producing glands and reducing oil production.
Moderate to severe pimples, inflamed skin thickening, mild and moderate eye or eyelid problems.
Moderate to severe rosacea that didn't respond to previous treatment, inflamed skin thickening that didn't respond to previous treatment.
Patients sensitive to doxycycline or other ingredients. Children under 8 years old should avoid this drug because of the risk of dental staining. Specific brands may have additional contraindications listed on the label.
Patients sensitive to isotretinoin, vitamin A, or other ingredients. Patients who are pregnant, breastfeeding, or have liver/kidney disease, high vitamin A, high blood fats, and who are also taking tetracyclines should not use this drug.
Doxycycline may slow the progression of skin thickening (case reports; very low certainty).
Isotretinoin may reduce early skin thickening (case reports; very low certainty).
Serious: skin darkening, enamel reduction, dental staining
Other: increased blood sugar, belly enlargement/pain, diarrhea, dry mouth, female genital infections.
Pregnancy: Doxycycline taken by a pregnant women can reach the baby and cause harm. Doxycycline should be avoided during pregnancy. Category D.
Serious: Risk of birth defects if a child is conceived while taking medication.
Other: Back pain, joint stiffness, muscle/bone disease, decreased bone density
Pregnancy: Category X; Not to be used in women who are or may become pregnant.
Involve taking pill(s) on a regular basis. Reminders for taking the pill(s) are required.
Involve taking pill(s) on a regular basis. Reminders for taking the pill(s) are required.
$+. Cost is based on price without insurance and may vary.
$$$. Cost is based on price without insurance and may vary.