Ivermectin works by reducing inflammation and skin mites (Demodex).
Metronidazole may reduce skin inflammation.
Azelaic acid may reduce skin inflammation.
Minocycline reduces inflammation in rosacea.
Mild to severe pimples.
Mild to severe pimples.
Mild to severe pimples.
Moderate to severe pimples.
Patients who are sensitive to ivermectin or other ingredients.
Patients who are sensitive to metronidazole or other ingredients of the formulations.
Patients sensitive to azelaic acid or other ingredients in the product.
People sensitive to minocycline or other ingredients.
This treatment has a 2 times greater chance of reducing pimples compared to no active treatment (high certainty).
This treatment has a 2 times greater chance of reducing pimples compared to no active treatment (moderate certainty).
This treatment has a 1.5 times greater chance of reducing pimples compared to no active treatment (high certainty).
1.5% topical minocycline has a 1.5 times greater chance of achieving almost clear skin or better than no active treatment (moderate certainty).
Serious: None
Other: Localized burning, Skin irritation
Pregnancy: Category C
Serious: None
Other: high blood pressure, headache, redness, inflammation, skin burning sensation, worsening of pimples, itchiness, skin irritation, stinging, sun sensitivity, urinary tract infection, local allergy, flu, upper respiratory tract infection
Pregnancy: Category B
Serious: None
Other: Skin burning sensation, stinging, tingling, itchiness, redness, skin irritation, acne, irritation, skin peeling, sun sensitivity, dry skin, pain
Pregnancy: Category B
Serious: None
Other: Burning sensation of skin, redness, peeling, itchiness, stinging, blood vessel lines, sun sensitivity, Flushing, diarrhea, headache.
Pregnancy: Topical minocycline should be avoided during pregnancy if possible. Category D.
Inconvenience (Reminders for application are required. Time is required for proper application of topical treatments.)
Inconvenience (Reminders for application are required. Time is required for proper application of topical treatments.)
Inconvenience (Reminders for application are required. Time is required for proper application of topical treatments.)
Inconvenience (Reminders for application are required. Time is required for proper application of topical treatments.)
$$$$. Cost is based on price without insurance and may vary.
$$$$. Cost is based on price without insurance and may vary.
$$$$. Cost is based on price without insurance and may vary.
$$$$. Cost is based on price without insurance and may vary.