Tetracyclines reduce inflammation in rosacea.
It is unclear how azithromycin works in rosacea.
Isotretinoin reduces the size of oil-producing glands and reducing oil production.
Moderate to severe pimples.
Moderate to severe pimples.
Moderate to severe rosacea pimples that didn't respond to previous treatment, inflamed skin thickening that didn't respond to previous treatment.
Patients sensitive to tetracyclines or other ingredients.
Minocycline: Patients with severe liver disease, kidney failure, certain immune system diseases (myasthenia gravis), or are pregnant/breastfeeding should avoid these drugs.
Patients sensitive to azithromycin, erythromycin, other macrolide (eg, azalide or ketolide) antibiotics, or other ingredients. Patients with gallbladder/liver disease caused by prior azithromycin use.
Patients sensitive to isotretinoin, vitamin A, or other ingredients. Patients who are pregnant, breastfeeding, or have liver/kidney disease, high vitamin A, high blood fats, and who are also taking tetracyclines should not use this drug.
Doxycycline is 2 times more effective at reducing pimples of rosacea compared to no active treatment (high certainty).
Minocycline is non-inferior to doxycycline (low certainty).
Azithromycin has the same chance of reducing pimples as doxycycline (very low certainty).
This treatment has about a 6 times greater chance of reducing pimples by 90% compared to no active treatment (high certainty).
Skin darkening, reduced enamel, dental staining
Serious specific to minocycline: certain immune system conditions (e.g. drug induced lupus, autoimmune hepatitis.)
Other: Burning sensation, redness, skin peeling, darkening, itchiness, stinging, blood vessel lines, sun sensitivity, flushing, diarrhea, headache, increased blood glucose, belly enlargement, belly pain, diarrhea, upper belly pain, dry mouth, female genital fungal infections.
Pregnancy: Tetracyclines taken by the mother can reach the baby and cause harm. These drugs should be avoided during pregnancy. Category D.
Serious: heart problems, gut infections/diarrhea, liver inflammation, allergic reactions.
Other: Diarrhea/constipation, nausea/vomiting. chest pain, facial swelling, heart racing, sweating, eczema, itchiness, light sensitivity, rash/hives, belly discomfort, fungal infection, vaginal inflammation, agitation, dizziness, drowsiness, fatigue, headache, insomnia, muscle spasms,, throat spasm, cough, water in the lungs, fever.
Pregnancy: Azithromycin taken by the mother can reach the baby. Category B.
Serious: Risk of birth defects if a child is conceived while taking medication.
Other: Back pain, joint stiffness, muscle/bone disease, decreased bone density.
Pregnancy: Category X; Not to be used in women who are or may become pregnant.
Involve taking pill(s) on a regular basis. Reminders for taking the pill(s) are required.
Involve taking pill(s) on a regular basis. Reminders for taking the pill(s) are required.
Involve taking pill(s) on a regular basis. Reminders for taking the pill(s) are required.
$+. Cost is based on price without insurance and may vary.
$. Cost is based on price without insurance and may vary.
$$$. Cost is based on price without insurance and may vary.