Systemic (Pill) Treatments

  • What is it and how does it work?
  • Who is it for?
  • Who is it not for?
  • How well does it work?
  • What are the possible side effects?
  • Will it inconvenience me?
  • How much does it cost?

Systemic (Pill) Treatments

What is it and how does it work?

Beta blockers (propranolol, carvedilol)

These work by narrowing widened blood vessels (vasoconstriction) to reduce blood flow to the skin surface, leading to less facial redness.

Who is it for?

Severe facial redness and moderate to severe flushing.

Who is it not for?

Some people may be sensitive to beta blockers or components of the drugs. These drugs should not be taken by patients with various heart conditions, various breathing conditions including COPD and asthma, blood vessel blockages, and diabetes. Check with your health care professional to make sure this treatment is right for you.

How well does it work?

There is some evidence that these medicines are helpful (case reports, low to very low certainty evidence.)

What are the possible side effects?

Serious: Heart problems, breathing problems, low glucose, high potassium and beta blocker withdrawal.

Other: Depression, fatigue, dizziness, sexual dysfunction, weight gain, tingling/cold hands and feet, headache, trouble sleeping/disturbing dreams, upset stomach, diarrhea or constipation.

Pregnancy: Most beta blockers, including propranolol and carvedilol, are pregnancy risk category C.

Will it inconvenience me?

Involves taking pill(s) on a regular basis. Reminders for taking the pill(s) are required.

How much does it cost?

$+. Cost is based on price without insurance and may vary.